{"id":346,"date":"2025-04-23T14:21:29","date_gmt":"2025-04-23T05:21:29","guid":{"rendered":"http:\/\/dgprt.brc.riken.jp\/en\/%e3%83%9b%e3%83%bc%e3%83%a0%e3%83%9a%e3%83%bc%e3%82%b8"},"modified":"2025-05-14T17:27:10","modified_gmt":"2025-05-14T08:27:10","slug":"%e3%83%9b%e3%83%bc%e3%83%a0%e3%83%9a%e3%83%bc%e3%82%b8","status":"publish","type":"page","link":"http:\/\/dgprt.brc.riken.jp\/en\/","title":{"rendered":""},"content":{"rendered":"
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  • \n\t\t\t\t\t\t\"RIKEN\t\t<\/li>\n\t\t\t\t
  • \n\t\t\t\t\t\t\"Decoding\t\t<\/li>\n\t\t\t\t
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      Welcome to Sakashita Lab !<\/span><\/h3>\n
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      How the fertilized egg orchestrates the formation of multicellular organs and an entire organism, while establishing the germ cell lineage to ensure the continuity of life, is a central question in developmental biology. Our research direction converges on unraveling the fundamental mechanisms by which early embryos invoke such a high developmental genome plasticity. To this end, we dissect the dynamics of epigenetic remodeling and transcriptional network activation, as well as the functional roles of non-coding genetic reservoirs, including transposable elements. In parallel, we explore the evolutionary diversity of developmental programs through cross-species comparative analyses. Our research outcome will provide new insight regarding the functions of non-coding genetic reservoirs in regulating genome plasticity during germline development, which will ultimately contribute to reproductive and regenerative medicine.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

      \n\t\t\t\n\t\t\n\t\t\t\n\t\t\tJoin Us (Opening information)\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div>
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      Our goal is to elucidate the epigenetic regulatory mechanisms underlying cell fate specification and maintenance to understand molecular systems in development and diseases.
      \n\u200bRead more >>Research<\/a>\u200b<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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      \n\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t2025-04-01\t\t\t\t<\/a>\t\t\t<\/span>\n\t\t\n\t\t\n\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t

      The Research Team was launched<\/a><\/h2>\t\t\t\t<\/header>\n\n\t\t\t\t
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      Apr. 1st, 2025     Our lab, the Developmental Genome Plasticity Research Team, has been launched at RIKEN BRC !...<\/p>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t\t<\/article>\n\n\t\n\t<\/div>\n\n\t<\/div><\/div><\/div>

      \n\t\t\t\n\t\t\n\t\t\t\n\t\t\tTsukuba\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div>
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      RIKEN BRC is located in Tsukuba City, a hub focused on advanced research and education. It offers rich green living environment and convenient access to the Tokyo metropolitan area.
      \n\u200b>>Access<\/a>\u200b<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

      How the fertilized egg orchestrates the formation of multicellular organs and an entire organism, while establishing the germ cell lineage to ensure the continuity of life, is a central question in developmental biology. Our research direction converges on unraveling the fundamental mechanisms by which early embryos invoke such a high developmental genome plasticity. To this end, we dissect the dynamics of epigenetic remodeling and transcriptional network activation, as well as the functional roles of non-coding genetic reservoirs, including transposable elements. In parallel, we explore the evolutionary diversity of developmental programs through cross-species comparative analyses. Our research outcome will provide new insight regarding the functions of non-coding genetic reservoirs in regulating…<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"home-panels.php","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-346","page","type-page","status-publish","hentry","post"],"_links":{"self":[{"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/comments?post=346"}],"version-history":[{"count":4,"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/346\/revisions"}],"predecessor-version":[{"id":371,"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/346\/revisions\/371"}],"wp:attachment":[{"href":"http:\/\/dgprt.brc.riken.jp\/en\/wp-json\/wp\/v2\/media?parent=346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}